Fig. 2: Control condition, simulated primary motor cortex (M1) activity, comparing resting state to movement state.
From: Enhanced beta power emerges from simulated parkinsonian primary motor cortex
A Resting state (250 ms at midpoint of 4.3 s simulation) displayed dominant beta-band activity (~20 Hz; particularly clear in the PT5B spike count histogram). Top-to-bottom: local field potential (LFP), raster plot (red excitatory; black inhibitory neurons), PT5B spike count histograms (2 ms bins; dashed lines at half height), and 5 randomly chosen PT5B voltage traces. B Activated state showed change to high-frequency gamma-band activity (~44 Hz). Same top-to-bottom as in A; bottom traces are the same neurons as in (A). C Statistically significant change was found for firing rates for excitatory cell types going from rest to activated: IT2/3 – rest: 1.2 ± 1.6 spikes/s; activated: 6.7 ± 8.9 spikes/s; PT5B – 11.7 ± 9.4 vs 26.8 ± 18.2 spikes/s; IT6 neurons – 5.8 ± 5.8 vs 3.5 ± 5.2 spikes/s (mean, std dev, range shown; ***p < 0.001; #: truncated maximum rate 73 spikes/s; calculated from the last 2.3 s of 4.3 s simulation to avoid initialization transients).
