Table 1 Demographic and clinical characteristics of PD patients and controls
PD | HCs | P value | |||
|---|---|---|---|---|---|
LPD | RPD | LPD vs RPD | PD vs HCs | ||
n | 36 | 27 | 49 | ||
Clinical variables | |||||
Age (y) | 62.64 ± 6.40 | 61.41 ± 7.35 | 63.39 ± 4.97 | 0.481 | 0.227 |
Gender (Male/Female) | 21/15 | 15/12 | 30/19 | 0.825 | 0.663 |
Education duration (y) | 10.42 ± 3.83 | 10.19 ± 4.10 | 11.40 ± 2.98 | 0.819 | 0.109 |
Disease duration (y) | 5.65 ± 3.33 | 6.05 ± 3.75 | NA | 0.662 | NA |
H &Y stage | 2.11 ± 0.75 | 2.11 ± 0.67 | NA | 0.986 | NA |
LEDD (mg/d) | 725.00 (431.25, 981.25) | 587.50 (328.13, 692.63) | NA | 0.074 | NA |
Motor symptom | |||||
UPDRS-III score | 30.58 ± 16.31 | 30.89 ± 10.79 | NA | 0.933 | NA |
Bradykinesia score | 15.13 ± 7.96 | 16.44 ± 6.44 | NA | 0.573 | NA |
Rigidity score | 7.83 ± 3.81 | 8.28 ± 4.21 | NA | 0.721 | NA |
PIGD score | 5.31 ± 4.38 | 5.33 ± 4.02 | NA | 0.980 | NA |
TD score | 5.50 (2.00, 10.00) | 4.50 (2.00, 9.00) | NA | 0.823 | NA |
Motor performance | |||||
TUG (s) | 14.14 ± 4.63 | 11.70 ± 5.36 | NA | 0.066 | NA |
Tinetti Gait score | 9.20 ± 2.82 | 8.93 ± 3.29 | NA | 0.725 | NA |
Tinetti Balance score | 13.51 ± 3.74 | 13.78 ± 2.69 | NA | 0.758 | NA |
FOG score | 1.00 (0.00, 10.00) | 1.00 (0.00, 8.00) | NA | 0.958 | NA |
Mental and cognitive impairment | |||||
MMSE score | 27.09 ± 2.30 | 28.07 ± 1.69 | 28.92 ± 1.06 | 0.067 | <0.001* |
FAB score | 16.09 ± 1.84 | 15.85 ± 2.32 | 17.00 ± 1.07 | 0.659 | 0.003* |
HARS score | 11.71 ± 7.03 | 11.63 ± 7.66 | 3.35 ± 3.58 | 0.964 | <0.001* |
HDRS score | 13.35 ± 10.81 | 13.32 ± 9.01 | 1.73 ± 2.27 | 0.992 | <0.001* |
AS score | 14.14 ± 7.01 | 11.72 ± 4.91 | NA | 0.225 | NA |
Sleep disorders | |||||
ESS score | 8.00 (3.00, 12.00) | 4.00 (3.00, 8.00) | NA | 0.131 | NA |
PDSS score | 122.81 ± 23.84 | 122.96 ± 23.46 | NA | 0.981 | NA |
RBDSQ score | 4.92 ± 3.65 | 4.00 ± 3.17 | NA | 0.302 | NA |
