Fig. 1: Lrrk2 G2019S mutation does not interfere with C. rodentium colonization and clearance. | npj Parkinson's Disease

Fig. 1: Lrrk2 G2019S mutation does not interfere with C. rodentium colonization and clearance.

From: Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis

Fig. 1

A Experimental design. Male and female Lrrk2 G2019S and WT mice (male-to-female ratio = 0.67) were gavaged once with ~1 × 109 colony-forming units (CFUs) of C. rodentium. Bacterial fecal shedding was quantified on days 4, 7, or 8, 12, 21, and 28 after infection. B CFUs per g of feces. Data are represented as mean ± SD and analyzed by two-way ANOVA with Sidak post-test. One representative of two independent experiments is presented. n = 5 mice per group. C Comparison fecal CFU C. rodentium burden in WT and G2019S mice on day 7 of infection, separated by sex. Data are represented as mean ± SD and analyzed by t-test. Ten independent experiments are presented. n = 64–65 mice per group. Dashed lines indicate the limit of detection (LOD).

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