Fig. 4: More strongly sonicated α-syn mPFFs inoculated into the nasal cavity and stomach show higher seeding activity. | npj Parkinson's Disease

Fig. 4: More strongly sonicated α-syn mPFFs inoculated into the nasal cavity and stomach show higher seeding activity.

From: Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson’s disease

Fig. 4

A–D The left OB is evaluated 2 months after intranasal administration of S5 or W5 (mPFFs) in mice (n = 6). A, C Representative images of the left OB showing IHC staining with antibodies against p-α-syn after S5 or W5 administration. Scale bar: 200 µm. B, D Magnified view of the glomerular layer. Scale bar: 50 µm. E, F The DMX is investigated 2 months after injection of S5 or W5 into the stomach of mice (n = 6). E Representative images showing IHC staining with antibodies against p-α-syn. Scale bar: 200 µm. F An analysis of the p-α-syn positive area following stomach injection of mPFFs. Propagation of S5 is stronger than that of W5. Each plotted dot represents the average of four areas, and six independent experiments are analyzed. The Mann-Whitney U test is performed; *p = 0.004.

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