Fig. 1: Longevity and motility analyses of flies ubiquitously or pan-neuronally expressing α-Syn. | npj Parkinson's Disease

Fig. 1: Longevity and motility analyses of flies ubiquitously or pan-neuronally expressing α-Syn.

From: Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinson’s Disease

Fig. 1

A, B Longevity curves of adult female (left) and male (right) flies expressing zero (black), one (green), or two (pink) copies of α-Syn throughout development and adulthood, driven by (A) sqh-Gal4 and (B) elav-Gal4. Median survival days are indicated to the right of each panel. Statistical significance was assessed using log-rank tests: ns (not significant), *(p < 0.05), **(p < 0.01), ***(p < 0.001), ****(p < 0.0001). C Diagram illustrating methodology of the Rapid Iterative Negative Geotaxis (RING) assay. For details, please see the Methods section. D, E Motility analysis (RING assay) of flies with (D) ubiquitous and (E) pan-neuronal α-Syn expression, with the week of measurement indicated at the top. Each vial was divided into five zones, with different colors representing each zone. Flies were photographed, and the number of flies in each zone was counted and normalized to the total number of flies. The percentage of flies in each zone is shown in the figure.

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