Fig. 6: Brain-region-specific changes in the ratios of hydroxylated to non-hydroxylated (t/d) SHexCers between Ctrl and MPTP, and non-LID and LID groups. | npj Parkinson's Disease

Fig. 6: Brain-region-specific changes in the ratios of hydroxylated to non-hydroxylated (t/d) SHexCers between Ctrl and MPTP, and non-LID and LID groups.

From: Brain-region-specific lipid dysregulation in L-DOPA-induced dyskinesia in a primate model of Parkinson’s disease

Fig. 6

a Schematic of a coronal non-human primate brain tissue section at −4 mm from the ac depicting different brain regions, with those evaluated labelled in red. Representative images of the [M-H]− ion of SHexCer(t42:2) normalized to the [M-H]− ion of SHexCer(d42:2) in (from left to right) b Ctrl, c MPTP, d non-LID, and e LID brain tissue sections at −4 mm from the ac. All ion distribution images are scaled to the maximum intensity of the individual ion. The ion images are RMS-normalized in panels b–e. Lateral resolution: 150 µm; scale bar: 9 mm. Results of statistical analysis using Student’s t-test of f SHexCer(t/d42:2), g SHexCer(t/d43.2), and h SHexCer(t/d40:1) in the GPi. Changes were evaluated between Ctrl and MPTP, and non-LID and LID. i Heat maps showing z-scores of several detected long-chain SHexCer(t/d) in the GPi, GPe, Cd and Put basal ganglia brain regions. Changes were statistically evaluated between Ctrl and MPTP, and non-LID and LID, independently. Asterisks indicate significance: *P < 0.05; **P < 0.01; ns: not significant. Asterisks in the MPTP and LID columns show results of statistical analysis between Ctrl vs. MPTP groups and LID vs. non-LID groups, respectively.

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