Fig. 5: The isSID assay confirms that pathological α-syn and tau inclusions possess seeding potential. | npj Parkinson's Disease

Fig. 5: The isSID assay confirms that pathological α-syn and tau inclusions possess seeding potential.

From: Novel in situ seeding immunodetection assay uncovers neuronal-driven alpha-synuclein seeding in Parkinson’s disease

Fig. 5

In PD cases, α-syn-isSID labeled pathological α-syn aggregates in LBs, neuronal, and neuritic inclusions, as well as in astrocytes, oligodendrocytes, and on the periphery associated with an Aβ plaque. Blue arrows indicate dot-like pathology. In MSA cases, the α-syn-isSID confirmed seeding capacity in GCIs, punctate GCIs, as well as neuronal inclusions, including NCIs, NNIs, and neurites. In AD cases, tau-isSID detects seeding potential within pathological tau structures, including pretangles, mature neurofibrillary tangles, ghost tangles, neuropil threads, dot-like pathology, and neuritic plaques. Scale bar is 50 µm.

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