Fig. 6: Truncated α-syn species originating from PFFs proteolysis by EVs do not trigger the recruitment and aggregation of the endogenous α-syn in recipient neurons. | npj Parkinson's Disease

Fig. 6: Truncated α-syn species originating from PFFs proteolysis by EVs do not trigger the recruitment and aggregation of the endogenous α-syn in recipient neurons.

From: Proteolytic activities of extracellular vesicles attenuate A-synuclein aggregation

Fig. 6

Confocal microscopy images of primary cortical neurons labelled for endogenous mouse α-syn (rα-Synuclein D37A6), 5 days in vitro (DIV), neuronal cells were treated with PFFs or EVs-cleaved PFFs for (A) 48 h and (B) 96 h. Untreated cells were used as control. TUJ1 and DAPI were used to stain neurons and neuronal nuclei, respectively. Scale bar represents 50 μm.

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