Fig. 6: Effects of CAP and Nic on microglia in the olfactory bulb and anterior olfactory nucleus of MPTP-induced mice. | npj Parkinson's Disease

Fig. 6: Effects of CAP and Nic on microglia in the olfactory bulb and anterior olfactory nucleus of MPTP-induced mice.

From: Capsaicin and nicotine alleviate MPTP induced olfactory dysfunction by suppressing cGAS/TBK1/STING and MAPK mediated neuroinflammation

Fig. 6

a Representative immunofluorescence images of Iba1 and CD68 in the granule cell layer of the olfactory bulb; b Representative immunofluorescence images of Iba1 and CD68 in the anterior olfactory nucleus; c Ibar positive cells in the granule cell layer; d Iba1 and CD68 co-localization in the granule cell layer; e Iba1 endpoints in the granule cell layer; f Iba1 process length in the granule cell layer; g Ibar positive cells anterior olfactory nucleus; h Iba1 and CD68 co-localization in the anterior olfactory nucleus; i Iba1 endpoints in the anterior olfactory nucleus; j Iba1 process length in the anterior olfactory nucleus. Iba1: green; CD68: red; DAPI: blue; Images were captured using a 63× objective, scale bar = 25 μm;enlarge scale bar = 2.5 μm. (n = 6 mice per group for a–j). Statistical analyses were performed by one-way ANOVA followed by Tukey’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001.

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