Fig. 3: Structural brain changes and subjective cognitive decline.
From: Subjective cognitive decline in individuals with isolated REM sleep behavior disorder
a Voxel-Based Morphometry (VBM) comparison between individuals with isolated REM sleep behavior disorder with (RBD.SCD+) and without (RBD.SCD–) subjective cognitive decline (SCD). Magenta indicates reduced grey matter (GM) volume in RBD.SCD+ compared to RBD.SCD– at pFDR < 0.05 in parametric VBM analysis. Red highlights areas significant at p < 0.01 (uncorrected) following threshold-free cluster enhancement (TFCE). b Association between GM volume in the left superior frontal gyrus (SFG) and the SCD-Severity score of the Multiple Domain Subjective Cognitive Decline Evaluation (Multi-SubCoDE) and the global cognition composite score. Dots represent observed values; the line indicates the linear relationship between the two variables with 95% confidence interval.
