Table 2 ACQ-7 responder rates, exacerbations and AEs.
From: Comparing LAMA with LABA and LTRA as add-on therapies in primary care asthma management
Reference | Drug vs comparator | Asthma control (measured as mean difference in ACQ) | Patients reporting ≥1 exacerbation | Patients reporting AEs |
|---|---|---|---|---|
LABA vs placebo | ||||
Paggiaro et al.23 | Beclomethasone/formoterol fumarate 400/12 µg BID vs beclomethasone 400 µg BID | ↔ | ✓ | ↔ |
Ducharme et al.16 | Formoterol or salmeterol vs placebo | NR | ✓ | NR |
Kerstjens et al.21 | Salmeterol 50 µg BID vs placebo | ✓✓ | ✓ | ↔ |
Bateman et al.22 | Salmeterol 50 µg BID vs placebo | NR | ✓ | ↔ |
LTRA vs placebo | ||||
Djukanovic et al.24 | Montelukast 10 mg QD vs placebo | NR | ↔ | NR |
ALAACRC32 | Montelukast 10 mg QD vs placebo | ↔ | NR | NR |
Vaquerizo et al.25 | Montelukast 10 mg QD vs placebo | NR | ✓ | ↔ |
Virchow et al.26 | Zafirlukast 80 mg BID vs placebo | NR | ✓✓ | ↔ |
LAMA vs placebo | ||||
Paggiaro et al.28 | Tiotropium 5 µg QD vs placebo | ↔ | NR | ↔ |
Paggiaro et al.28 | Tiotropium 2.5 µg QD vs placebo | ↔ | NR | ↔ |
Ohta et al.29 | Tiotropium 5 µg QD vs placebo | ✓ | NR | ↔ |
Ohta et al.29 | Tiotropium 2.5 µg QD vs placebo | ✓ | NR | ↔ |
Timmer et al.31 | Tiotropium 5 µg QD vs placebo | ✓✓ | NR | ↔ |
Timmer et al.31 | Tiotropium 2.5 µg BID vs placebo | ✓✓ | NR | ↔ |
Beeh et al.30 | Tiotropium 5 µg QD vs placebo | ✓✓ | NR | ↔ |
Beeh et al.30 | Tiotropium 2.5 µg QD vs placebo | ✓✓ | NR | ↔ |
Beeh et al.30 | Tiotropium 1.25 µg QD vs placebo | ✓✓ | NR | ↔ |
Kerstjens et al.27 | Tiotropium 5 µg QD vs placeboa | ✓ | ✓✓c | ↔ |
Kerstjens et al.27 | Tiotropium 5 µg QD vs placebob | ✓✓ | ✓✓c | ↔ |
Kerstjens et al.21 | Tiotropium 5 µg QD vs placebo | ✓✓ | ✓ | ↔ |
Kerstjens et al.21 | Tiotropium 2.5 µg QD vs placebo | ✓✓ | ✓✓ | ↔ |
Bateman et al.22 | Tiotropium 5 µg QD vs placebo | NR | ✓ | ↔ |
LABA vs LTRA | ||||
Chauhan and Ducharme15 | Salmeterol/formoterol vs montelukast/zafirlukast | NR | ✓✓ | ↔ |
LAMA vs LABA | ||||
Kerstjens et al.21 | Tiotropium 5 µg QD vs salmeterol 50 µg BID | ↔ | ↔ | ↔ |
Kerstjens et al.21 | Tiotropium 2.5 µg QD vs salmeterol 50 µg BID | ↔ | ↔ | ↔ |
Wechsler et al.34 | Tiotropium 18 µg QD vs salmeterol 50 µg or formoterol 9 µg BID | ↔ | ↔ | ↔ |
Bateman et al.22 | Tiotropium 5 µg QD vs salmeterol 50 µg BID | NR | ↔ | ↔ |
Peters et al.33 | Tiotropium 18 µg QD vs salmeterol 50 µg BID | ↔ | ↔ | ↔ |
