Table 1 Asthma control in medium- and high-dose ICS/LABA cohort and reasons for uncontrolled asthma control.

From: Uncontrolled asthma: a retrospective cohort study in Japanese patients newly prescribed with medium-/high-dose ICS/LABA

 

Medium-dose ICS/LABA cohort (N = 24,937)

High-dose ICS/LABA cohort (N = 8661)

Patients with uncontrolled asthma

5707 (22.9%)

1793 (20.7%)

Reasons for uncontrolled asthma

Episode of exacerbation

Moderate exacerbation

1455 (5.8%)

676 (7.8%)

Severe exacerbation

197 (0.8%)

92 (1.1%)

Treatment step up

ICS increased dose

442 (1.8%)

0

Addition of LAMA

10 (0.0%a)

11 (0.1%)

Addition of LTRA

1920 (7.7%)

495 (5.7%)

Addition of theophylline

594 (2.4%)

212 (2.5%)

Maintenance systemic corticosteroids

75 (0.3%)

31 (0.4%)

Addition of more than one asthma controller, including LTRA

198 (0.8%)

55 (0.6%)

Addition of more than one asthma controller, excluding LTRA

23 (0.1%)

0

High-dose SABA

568 (2.3%)

186 (2.2%)

Use of adrenaline

633 (2.5%)

169 (2.0%)

  1. Data are presented as n (%).
  2. ICS inhaled corticosteroid, LABA long-acting β2-agonist, LAMA long-acting muscarinic antagonist, LTRA leukotriene receptor antagonist, SABA short-acting β2-agonist.
  3. a0.04%.