Table 4 Clinical inputs.
Parameter | Values | Source/assumption | OWSA | |
---|---|---|---|---|
Lower | Upper | |||
COPD through FEV1 Decline (L/year)a | 0.041 | 0.033 | 0.049 | |
Annual probability to discover COPD from “undetected”b | ||||
Mild COPD | 20.00% | KOL interview | 16.00% | 24.00% |
Moderate COPD | 50.00% | KOL interview | 40.00% | 60.00% |
Severe/very severe COPD | 90.00% | KOL interview | 72.00% | 100.00% |
Treatment effects (mean change in through FEV1 L/month) | ||||
LAMA + LABA | 0.026 | Supplementary Table 3 | 0.021 | 0.031 |
LABA + ICS | 0.031 | Supplementary Table 3 | 0.025 | 0.037 |
LABA alone | 0.013 | Supplementary Table 3 | 0.010 | 0.016 |
LAMA alone | 0.022 | Supplementary Table 3 | 0.018 | 0.027 |
LABA + LAMA + ICS | 0.025 | Supplementary Table 3 | 0.020 | 0.030 |
% COPD patient to develop exacerbation | ||||
Mild COPD | 19.00% | 15.20% | 22.80% | |
Moderate COPD | 19.00% | 15.20% | 22.80% | |
Severe/very severe COPD | 26.50% | 21.20% | 31.80% | |
% of exacerbations treated in hospital | ||||
Mild COPD | 68.42% | 54.74% | 82.11% | |
Moderate COPD | 68.42% | 54.74% | 82.11% | |
Severe/very severe COPD | 66.04% | 52.83% | 79.25% | |
Mortality of severe exacerbation | 1.28% | 0.50% | 10.00% | |
Risk of serious pneumonia | ||||
Monthly incidence of serious pneumonia | 0.20% | 0.16% | 0.25% | |
Mortality of serious pneumonia | 3.33% | 2.66% | 3.99% |