Table 4 Independent factors associated with adherence to MITT determined by the logistic regression model.

From: Characteristics and treatment patterns of patients with asthma on multiple-inhaler triple therapy in Spain

Variable and reference arm

Estimated adjusted OR of adherence to MITTa

95% CI

p-value in the model

Age at MITT initiation: older vs younger

1.047

1.025–1.070

<0.001

Having anxiety and depression: yes vs no

1.817

1.045–3.159

0.034

Previous sick leave of respiratory cause: yes vs no

2.616

1.235–5.541

0.012

Previous ICS/LABA use: yes vs no

0.528

0.308–0.904

0.020

  1. Adherence to MITT defined as PDC > 0.8.
  2. BMI body mass index, CI confidence interval, GP general practitioner, ICS inhaled corticosteroids, LABA long-acting β2-agonist, LAMA long-acting muscarinic antagonist, MITT multiple-inhaler triple therapy, PDC proportion of days covered, OCS oral corticosteroids, OR odds ratio.
  3. aHigher OR is associated with a greater likelihood of being adherent to MITT. Independent variables were age, sex, BMI, smoking status, comorbidities (pneumonia, sleep apnea syndrome, polyposis, allergic rhinitis, atopic dermatitis, conjunctivitis, gastroesophageal reflux, diabetes mellitus, hypertension, anxiety, depression), exacerbations, eosinophil count, chest X-ray, computerized tomography scan, allergy test, GP, nurse and pulmonologist visits, pneumologist and allergy referrals, sick leave, sick leave due to a respiratory cause, influenza and pneumococcal vaccines, and previous treatment (ICS, ICS/LABA, ICS/LABA/anti-leukotrienes, ICS/LABA/OCS/anti-leukotrienes, ICS/LAMA, LAMA, LABA/LAMA, LAMA/anti-leukotrienes, anti-leukotrienes, OCS, no treatment).
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