Table 2 Patient outcomes after RHCIII-MPC implantation: (A) Clinical outcomes after RHCIII-MPC implantation at last follow-up; (B) Symptoms before surgery and at last follow-up after RHCIII-MPC implantation

From: Biomaterials-enabled cornea regeneration in patients at high risk for rejection of donor tissue transplantation

A

             

Patient no.

Graft diam. (mm)

Suture removal (weeks after surgery)

Full epithelial coverage (weeks after surgery)

BCVA pre-op LogMAR

BCVA at last follow-up, LogMAR

IOP at last follow-up in the operated eye (mmHg)

IOP at last follow-up fellow eye (mmHg)

Schirmer test at last follow-up operated (mm/5 min)

Schirmer test at last follow-up fellow (mm/5 min)

Corneal pachymetry Pre-op (µm)

Corneal pachymetry at last follow-up (µm)

Neovascularization of implant area at last follow-up

Follow-up (months)

1

6

8

4

LP

0·52

17

15

10

15+

250

470

No

24

2

8

3

12

1.6

0.1

14

12

16

20

484

270

No

35

3*

8

3

1.6

1·0

NA

NA

NA

NA

550

NA

NA

1.5

4

7

12

50

LP

1.7

13

14

15+

15+

1200

260

Yes

24

5

5

6

7

LP

1·3

19

18

6

10

320

320

Yes

14

6

4

12

48

NLP

NLP

25

15

14

14

410

560**

Yes

24

7

4

n/r

4

LP

1.3

16

16

9

8

220

1400

Yes

24

B

      

No.

Photophobia / pain

Tearing

Redness

 

Before

After

Before

After

Before

After

1

+

+

+

2

3

NA

NA

4

+

+

+

+

+

+

6

+

+

+

7

+

+

+

  1. *Patient 3 dropped out of the trial due to an unrelated fungal infection that was treated by penetrating keratoplasty. His last follow-up examination was at 1.5 months post-operation
  2. **18 months data
  3. LP—light perception; NLP no light perception, n/r not removed
  4. notes. ‘+’—symptom is present, ‘−’ —symptom is not present, ‘NA’—data not available
  5. §Patient 5 did not come in for his 24 m follow-up but reported no symptoms when interviewed over the telephone by surgeon, OB at 24 m