Table 2 Research interests and contact information for contributing institutions

From: The convergence of regenerative medicine and rehabilitation: federal perspectives

National Institutes of Health (NIH) [in rank order of current rehabilitation research spending]

Program official contacts

Rehabilitation research interests

1. National Institute of Neurological Disorders and Stroke (NINDS)

Dr. Daofen Chen:

daofen.chen@nih.gov

Dr. Lyn Jakeman:

lyn.jakeman@nih.gov

Dr. Pat Frost Bellgowan:

patrick.frostbellgowan@nih.gov

Dr. Scott Janis:

JanisS@ninds.nih.gov

Website: http://www.ninds.nih.gov/

Understanding the fundamental mechanisms and evidence for effectiveness of rehabilitation on progression, neural plasticity and recovery of function in animal models or human subjects with neurological disorders or disease, or following injury to the brain, spinal cord or peripheral nervous system

Research on the physiological mechanisms of environmental, socioeconomic, and demographic variables and disparities on effectiveness of rehabilitation interventions for individuals with neurological conditions

Research on the effective delivery and outcome assessment of rehabilitation interventions for individuals with neurological conditions across the lifespan and around the world

Precision based medicine research and identification of markers that inform mechanistic underpinnings and/or biological targets of action for neurorehabilitation therapies

Development and use of nervous system stimulation and recording devices and sensors that can detect responses or influence the activity of the nervous system for improved diagnosis and/or functional recovery

Approaches, tools and resources to improve the rigor and predictive power of preclinical, observational, and clinical studies in the area of neurorehabilitation

Exploratory and definitive clinical trials of rehabilitation interventions at the stage appropriate for the level of evidence and burden of disease or disability

2. National Institute of Deafness and Communication Disorders (NIDCD)

Dr. Lana Shekim:

shekiml@nidcd.nih.gov

Website: www.nidcd.nih.gov

Research to improve hearing healthcare (HHC) https://www.nidcd.nih.gov/research/improve-hearing-health-care

Studies on the rehabilitation of neurologic communication disorders (aphasia, dysarthria, and apraxia of speech)

Studies on neuromodulation in conjunction with behavioral therapy, for example, in management of tinnitus or in verbal expression

Research on augmentative and alternative communication (AAC) in conjunction with brain-computer interface (BCI) for communication

3. Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) National Center for Medical Rehabilitation Research (NCMRR, within NICHD)

Dr. Alison Cernich:

alison.cernich@nih.gov

Dr. Ralph Nitkin:

nitkinr@mail.nih.gov

Website: www.nichd.nih.gov www.nichd.nih.gov/about/org/ncmrr

Pathophysiology and management of chronically injured nervous and musculoskeletal systems (including stroke, traumatic brain injury, spinal cord injury, and orthopedic conditions)

Repair and recovery of motor and cognitive function

Functional plasticity, adaptation, and windows of opportunity for rehabilitative interventions

Rehabilitative strategies involving pharmaceutical, stimulation, and neuroengineering approaches, exercise, motor training, and behavioral modifications

Pediatric rehabilitation

Secondary conditions associated with chronic disabilities

Improved diagnosis, assessment, and outcome measures

Development of orthotics, prosthetics, and other assistive technologies and devices

4. National Institute on Aging (NIA)

Dr. Lyndon Joseph:

josephlj@mail.nih.gov

Website: www.nia.nih.gov

Exercise

Physical therapy

Pain management

Mobility

Gait

Technology

Robotics

5. National Cancer Institute (NCI)

Dr. Ann O’mara:

omaraa@mail.nih.gov

Dr. Julia Rowland:

rowlandj@mail.nih.gov

Website: www.cancer.gov

The management of acute and chronic as well as late morbidities associated with cancer. The impact of cancer and its treatment on a wide variety of patient outcomes, such as fatigue, neurocognitive impairments, neuropathies, sexual function, general physical functioning, has been documented. However, because of the paucity of evidence

The role of pre-habilitation as well as post-treatment rehabilitation in improving functional outcomes among cancer survivors. The unique contribution of rehabilitative services to cancer patient and survivors’ outcomes remains poorly understood. In addition, research is needed to test and evaluate the efficacy of different models of care delivery (timing, staffing, components, metrics for success) to determine the best way to integrate and deliver rehabilitative services across the cancer control continuum

6. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Dr. Charles H. Washabaugh:

washabac@mail.nih.gov

Website: http://www.niams.nih.gov/

Examining the impact of physical activity levels on bone health and fracture risk and developing and testing strategies to promote bone health through exercise and physical rehabilitation programs

Developing or modifying strategies, including preventive and rehabilitative approaches, to reduce the development of disability and functional limitation associated with OA onset and progression

Exploring rehabilitation and physical-therapy strategies to reduce risk for impairment from OA progression

Standardizing criteria for determining therapeutic effects of non-surgical interventions (such as drugs or rehabilitation strategies) to prevent or treat implant osteolysis

Developing and validating pre-operative and post-operative rehabilitation strategies, especially for hip and knee replacement

Applying physical medicine and rehabilitative strategies to soft-tissue injuries to restore maximal function

Determining types and levels of exercise effective for minimizing progression of specific diseases and promoting restoration of musculoskeletal function

7. National Heart, Lung, and Blood Institute (NHLBI)

Dr. Jerome Fleg:

flegj@nhlbi.nih.gov

Website: http://www.nhlbi.nih.gov/

Strategies to increase participation in cardiac and pulmonary rehabilitation programs

Reduction of disparities in cardiac and pulmonary rehabilitation participation by women, minorities, the elderly, and low income individuals

Development of new models for cardiac and pulmonary rehabilitation, including those incorporating telemedicine, fitness trackers, the Internet, and other novel technologies

8. National Eye Institute (NEI)

Dr. Tom Greenwell:

greenwellt@mail.nih.gov

Dr. Cheri Wiggs:

Cheri.Wiggs@nih.gov

Website: https://nei.nih.gov/

Assistive devices for individuals with visual impairment

Adaptive technologies and training specialized for low vision

New technologies (including prostheses) for restoring vision to the visually impaired

Rehabilitation strategies that address the special health problems and requirements of people with visual impairment

9. National Institute of Biomedical Imaging and Bioengineering (NIBIB)

Dr. Grace C.Y. Peng:

grace.peng@nih.gov

Dr. Michael Wolfson:

michael.wolfson@nih.gov

Website: www.nibib.nih.gov

Novel methods and technologies to interact with a patient, including neural interfaces, physical interfaces, and sensory interfaces

Novel sensors to monitor biomarkers of patient health and rehabilitation progress

Novel prostheses and orthoses to facilitate rehabilitation and restoration of function

Next generation computational models and intelligent methods for rehabilitation applications

10. National Institute of Nursing Research (NINR)

Dr. Lois Tully:

lois.tully@nih.gov

Website: http://www.ninr.nih.gov/

Symptom and self-management strategies aimed at maintaining, improving, or restoring functional abilities and quality of life in individuals with functional impairments or disabilities resulting from injury, aging, or chronic illness

Role of modifiable lifestyle and health behaviors on risk for initial disability (prevention) or on re-occurrence of the disability

Informal caregiving of individuals with a disability

Biological and psychosocial mechanisms underlying inter-individual variation in response to rehabilitation interventions

11. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Dr. Teresa Jones:

jonest@extra.niddk.nih.gov

Website: http://www.niddk.nih.gov/

Improvements in the diagnosis and treatment of bowel, bladder, and erectile dysfunction

Nutritional strategies to improve the quality of life for people with chronic kidney, gastrointestinal, endocrine, and metabolic diseases

Improving the functional status of individuals with end-stage renal disease

Gait, muscle, and peripheral nerve dysfunction secondary to diabetes

Improving function in individuals with foot deformities or amputations of their lower extremities from the complications of diabetes

The use of closed loop systems to compensate for the loss of beta cell function in type 1 diabetes

12. Office of Behavioral & Social Sciences Research (OBSSR)

Dr. Bill Elwood:

william.elwood@nih.gov

Website: https://obssr.od.nih.gov/

Improves the synergy of basic through applied behavioral and social science research findings through projects that more precisely target individual and social mechanisms and processes that improve health and wellbeing

Enhances measures, methods, and data infrastructure that encourage a more cumulative and integrated approach to social and behavioral aspects of rehabilitation research

Facilitates the adoption of behavioral and social research findings in rehabilitation health research and practice

13. Office of Dietary Supplements

Dr. Abby Gwen Ershow:

ershowa@od.nih.gov

Website: https://ods.od.nih.gov

Role of dietary supplements in maintaining and improving health and preventing chronic disease in individuals with mobility or other rehabilitation medicine issues

Methods for assessing dietary supplement use by individuals with vision or hearing impairments or using assistive technologies

Safety of nutritional, herbal, or botanical dietary supplements used by individuals with disabilities or participating in rehabilitation medicine activities

Role of dietary supplements in meeting nutrient needs for optimal growth and health in children with mobility impairments or feeding difficulties

Department of Defense (DoD)

Clinical & Rehabilitative Medicine Research Program (CRMRP)

Regenerative medicine portfolio, neuromusculoskeletal (NMS) injury rehabilitation portfolio

Program official contacts

Regenerative and rehabilitation research interests

Regenerative MedicineDr. Lloyd Rose lloyd.f.rose2.civ@mail.mil

NMS Injury Rehabilitation Dr. Erik Wolf erik.j.wolf6.civ@mail.mil

Website: https://crmrp.amedd.army.mil/

Efforts to replace or regenerate human cells, tissues or organs to restore or establish normal tissue function for regenerating traumatically injured tissues of the extremity and craniomaxillofacial injuries, burns and scarless wound healing, composite tissue transplantation

Efforts directed towards optimal treatment, rehabilitation, and reintegration following service-related neuromusculoskeletal injury including: service-related acute and repetitive overuse injury management, limb loss rehabilitation and prosthetic management, and limb trauma rehabilitation and orthotic management

Department of veterans affairs office of research and development

Basic Laboratory Research and Development (BLR&D) Service Trauma, Surgical and Musculoskeletal and Immune Disorders Portfolio Rehabilitation Research and Development (RR&D) Service Regenerative Medicine Portfolio RR&D Musculoskeletal and Co-morbidities Portfolio

Program official contacts

Rehabilitation research interests

BLR&D Dr. Kimberlee Potter

Kimberlee.potter@va.gov

RR&D Musculoskeletal and Co- morbidities Dr. Timothy Brindle

Timothy.brindle@va.gov

RR&D Regenerative Medicine Dr. Audrey Kusiak Audrey.kusiak@va.gov

Websites: www.research.va.gov

Research to develop strategies to replace or regenerate tissues or organs following traumatic injury or disease. The goal is to restore tissue function and increase the quality of life of veterans

Rehabilitation and target-directed activity-based efforts post cell transplantation to strengthen and facilitate proper connectivity/integration of regenerative approaches

Prehabilitation of subjects to maximize post-regenerative rehabilitation and timely recovery

Long-term safety and efficacy of cell-based regenerative approaches

Development of clinically relevant large animal models with scale-up and translational relevance

National Science Foundation (NSF)

Engineering of Biomedical Systems Program (EBMS)

Disability & Rehabilitation Engineering Program (DARE)

Program official contacts

Regenerative and rehabilitation research interests

Dr. Michele Grimm

mgrimm@nsf.gov

Website: https://www.nsf.gov/div/index.js p?div=CBET

Fundamental and transformative research in: the development of validated models (living or computational) of normal and pathological tissues and organ systems that can support development and testing of medical interventions; the design of systems that integrate living and non-living components for improved diagnosis, monitoring, and treatment of disease or injury; and advanced biomanufacturing of three-dimensional tissues and organs

Fundamental engineering research that will improve the quality of life of persons with disabilities through: development of new technologies, devices, or software; advancement of knowledge regarding normal or pathological human motion; or understanding of injury mechanisms