Fig. 1 | npj Regenerative Medicine

Fig. 1

From: Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization

Fig. 1

Development of implantable HA-DFO. a HA-DFO general chemical structure. b 1H-NMR spectra (D2O, 400 MHz) of HA (752 kDa)-DFO-MA and HA (752 kDa)-DFO confirming the characteristic peaks of MA (6.5–5.5 ppm), HA (4.0–3.0 ppm) and DFO (2.0–1.0 ppm), highlighted from left to right, respectively. The peak at δ = 4.70 in each spectrum corresponds to the solvent residue. c HA (752 kDa)-DFO-MA hydrogel before and after overnight incubation with iron. Note the rust color indicating successful iron chelation within the Hydrogel-Iron (III) complex. Scale bar length = 5 mm. d Percent molecular weight of unmodified HA (752 kDa), and its two derivatives in response to hyaluronidase enzymatic degradation

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