Fig. 4 | npj Regenerative Medicine

Fig. 4

From: Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization

Fig. 4

In vivo: HA-DFO restores mineralization and enhances biomechanical strength in irradiated fracture healing. a In vivo experimental timeline, normal peak fracture angiogenesis timing and schematic of the rat mandible depicting drug delivery methods and release kinetics. b Representative µCT images by treatment group. Notice the decreased bony bridging across the fracture site in the XFx sample that is restored in both iDFO and HA-DFO treated mandibles. c Radiomorphometrics: BMD, TMD, BVF, and (d) Biomechanical metrics: S and FL. ANOVA was performed for group comparisons. Group means are shown, and error bars indicate standard deviation. * indicates p < 0.05

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