Fig. 4: Dedifferentiation-reprogrammed mesenchymal stem cells with promising therapeutic potential for cartilage and nerves.
From: Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine
a Immunofluorescence staining revealed the preferential neuronal differentiation of De-MSCs, as evidenced by the higher expression of neuronal markers, including neurofilament-M (NF-M) and microtubule-associated protein 2 (MAP2) (used with permission from John Wiley and Sons/Hsiao et al.127). b Histology and immunohistochemistry revealed that the M-MSC group exhibited a greater therapeutic effect on OA, as evidenced by the increased ECM deposition, increased number of GFP-positive cells, and reduction in MMP-13 expression129 (Copyright 2017, with permission from Elsevier).
