Table 1 Comparison of different sources of cells for cell therapy.
hESCs | iPSCs | hNSCs | iPSC-derived hNSCs | MSCs | iPSC-derived MSCs | |
|---|---|---|---|---|---|---|
Ethical concerns | ! | ✓ | ! | ✓ | ✓ | ✓ |
Genomic stability | ! | ! | ✓ | ! | ✓ | ! |
Risk of tumor formation | ! | ! | ✓ | ! | ✓ | ! |
Allogenic and autologous source available | ! | ✓ | ! | ✓ | ✓ | ✓ |
Risk of immunological rejection | ! | ✓ | ! | ✓ | ✓ | ✓ |
Donor-age-related issues | ✓ | ! | ✓ | ! | ! | ✓ |
