Fig. 8: Network diagrams of selected gene ontology clusters enriched in 3D organoids and adult kidneys. | npj Regenerative Medicine

Fig. 8: Network diagrams of selected gene ontology clusters enriched in 3D organoids and adult kidneys.

From: Recapitulating kidney development in vitro by priming and differentiating mouse embryonic stem cells in monolayers

Fig. 8

a Over-represented gene ontologies enriched in 8D organoids compared to undifferentiated mouse embryonic stem cells (ESCs) include renal system development, extracellular matrix organization, blood vessel development, and anterior/posterior pattern formation. b Over-represented gene ontologies enriched in 8D organoids compared to adult kidneys include histone acetylation, histone methylation, metanephros development, and stem cell development, and maintenance. c Over-represented gene ontologies enriched in adult mouse kidneys compared to 8D organoids include regulation of pH, and anion, cation, carboxylic, and amine transport. FDR-corrected p < 0.05.

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