Fig. 2: LEV treatment promotes functional recovery after cervical SCI. | npj Regenerative Medicine

Fig. 2: LEV treatment promotes functional recovery after cervical SCI.

From: Levetiracetam treatment leads to functional recovery after thoracic or cervical injuries of the spinal cord

Fig. 2

a Grooming score test demonstrated that LEV promotes a significant functional recovery of the right forelimb. LEV-treated animals were capable of reaching the eye level with the lesioned paw, while saline-treated animals were only capable of reaching underneath the snout. b The behavioral analysis of the staircase test revealed that LEV-treated animals were able to eat more sugar pellets with the right forepaw when compared to saline-treated rats. c The gridwalk test was also performed to complement fine locomotor recovery assessment. LEV treatment was able to significantly reduce the rate error of the animals while exploring the grid. d Finally, the elbow pasta test was also performed to assess bimanual dexterity of the rats. On this behavioral analysis, LEV-treated animals demonstrated higher motor abilities being able to eat the pasta with both forepaws for longer time periods than the saline treatment rats. Sham n = 3; Saline n = 6; LEV n = 8. Values shown as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

Back to article page