Fig. 4: The effect of LEV on cavity size, motor neurons survival, and CST axons preservation. | npj Regenerative Medicine

Fig. 4: The effect of LEV on cavity size, motor neurons survival, and CST axons preservation.

From: Levetiracetam treatment leads to functional recovery after thoracic or cervical injuries of the spinal cord

Fig. 4

a Mean cavity size distribution along the rostral-caudal axis of LEV and saline-treated animals, b Cavity quantification revealed that LEV treatment significantly reduced cavity size after SCI. Sham animals did not presented any cavitation. c GFAP + staining was used to demarcate the cavity of both LEV and saline-treated animals. d The sum of motor neurons was determined at rostral, caudal and epicenter regions. LEV treatment was able to significantly protect motor neurons at epicenter and caudal regions. e Representative confocal photomicrographs of NeuN+ cells. f Rostral-caudal distribution of positive neuronal fiber staining at CST. g Quantification of βIII-Tubulin+ staining at CST revealed significant neuronal fiber preservation on LEV-treated rats. h Representative confocal photomicrographs of βIII-Tubulin+ staining. Values shown as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001. Scale bar = 400 µm. Sham n = 3; Saline n = 8; LEV n = 14.

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