Fig. 5: Crosstalk between noncardiomyocyte and cardiomyocytes in exercise-induced cardiac protection.
From: Targets identified from exercised heart: killing multiple birds with one stone
Exercise promotes the expression of exosomal-nuclear factor-erythroid 2 related factor 2 (Nrf2)/metallothioneins (Mts) in cardiac fibroblasts, inhibiting cardiomyocyte reactive oxidative species (ROS) production and cell apoptosis. Endotheliocytes produce EVs (containing miR-342-5p) and deliver to cardiomyocyte, leading to an increase in the antiapoptosis capacity via inhibiting caspase 9 as well as c-Jun N-terminal kinase (JNK2).
