Fig. 1: Considerations for clinical stem-cell manufacturing. | npj Regenerative Medicine

Fig. 1: Considerations for clinical stem-cell manufacturing.

From: Induced pluripotency in the context of stem cell expansion bioprocess development, optimization, and manufacturing: a roadmap to the clinic

Fig. 1

a Ideal stem-cell population dynamics in the presence of adequate process control and intervention strategies. Maintenance of high-quality phenotype is critical in ensuring safety and efficacy in derived products. b Erosion of phenotype in the presence of inadequate process control and intervention, the result of which may take the form of genetic defects, elicitation of immune response by the host, abnormal function, cell cycle de-regulation, and tumorigenesis.

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