Fig. 1: Characteristics of Acomys heart physiology and anatomy at baseline.
From: Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
a–j Measures of body weight (BW) and heart weight in C57BL6-Mus (N = 10), CFW-Mus (N = 19), and Acomys (N = 22). Analyses demonstrate comparable heart weight across species when normalized by body weight (BW) and tibia length (TL) (values are means ± S.E.M, *P < 0.05, **P < 0.01, and ***P < 0.001 by one-way ANOVA and Dunnett correction with Acomys as control). Ejection fraction (F = 4.1, *P < 0.05) (e), fractional shortening (F = 0.96, P > 0.05) (f), left ventricular end-diastolic diameter (LVEDD) (F = 14.8, **P < 0.01) (g), left ventricular end-systolic diameter (LVESD) (F = 4.6) (h), left ventricular anterior wall (LVAW) (F = 14.9, *P < 0.05) (i), left ventricular posterior wall (LVPW) (F = 6.4) (j) (N = 30 C57BL6-Mus, 10 CFW-Mus and 10 Acomys). Representative images showing comparable left anterior descending artery coronary anatomy across species using intra-aortic infusion of Batson’s 17 polymer mixture and corrosion casting (N = 5 each group, scale bar = 1 mm) (k). Quantification of coronary branching points of the arterial supply of the left ventricle across species. This analysis shows a comparable number of branching points across species with numerically higher (but not statistically significant) branching points in C57BL6-Mus and Acomys compared to CFW-Mus (l). Detailed statistical output for this figure can be found in the Supplementary Information.
