Fig. 6: Cardiac scar tissue exhibits limited expansion in Acomys.
From: Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
a Representative images of Masson’s trichrome stained long-axis left ventricular cavity sections of Mus (C57BL6 and CFW) and Acomys in uninjured and MI animals at 7-, 17- and 50-days post-MI showing the progression of scar across species (scale bar = 500 μm). The lower panels represent the boxed areas and show the composition of the scar at each stage. b, c Quantification of the infarct size, corresponding to the ratio between infarcted length and left ventricular length showing significantly smaller scar in Acomys compared to Mus strains (N = 17 Mus-C57BL6, 11 Mus-CFW, and 5 Acomys, values are means ± S.E.M, *P < 0.05 by one-way ANOVA and Tukey’s multiple comparison test). d Scar progression in Acomys and Mus-C57BL6 showing dynamic reduction in infarct size in Acomys in contrast to the larger static scar in Mus-C57BL6 (*P < 0.05, **P < 0.01, and ***P < 0.001 as analyzed using 2-way independent ANOVA).
