Fig. 2: Near-absence of infarction-induced remodeling in Acomys.
From: Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)
a Infarct size of mice injected with Evans blue 24 h after surgery. Unpaired t test. b TUNEL-reactive dying cells (yellow arrows) in the scar area of infarcted hearts. Scale bar = 50 µm. c Heart to body weight ratio progression over time. d Heart size progression, based on transversal stacks stained with Masson’s Trichrome (see ‘Methods’). e Heart wall thickness derived from five points-of-measurements along the scar wall. f Relative gene expression from whole heart ventricle homogenates subjected to RT-qPCR. Samples have been normalized to the sham-control (Acomys or Mus). b−f Two-way mixed ANOVA followed by Bonferroni post hoc test. For all comparisons: * is significant compared to Acomys-sham, # compared to Mus-sham, $ is significant in an inter-species comparison of the same time point (e.g. 100 days to 100 days). * is p < 0.05, ** is p < 0.01, and *** is p < 0.001. Box plots represent the median, interquartile range (IQR), minimum (25th percentile – 1.5 × IQR), and maximum (75th percentile – 1.5 × IQR). All bar graphs represent the mean ± standard error of the mean (SEM).
