Fig. 8: Glycopyrrolate promotes re-innervation at multiple subcortical visual targets.
From: Clinically relevant small-molecule promotes nerve repair and visual function recovery
a–f Representative confocal micrographs demonstrated that a considerable number of CTB-labeled regenerating RGC axons were detected in (a) hypothalamic suprachiasmatic nucleus (SCN), (b) optic tract (OT), (c) thalamic ventral lateral geniculate nucleus (vLGN), (d) dorsal lateral geniculate nucleus (dLGN), (e) olivary pretectal nucleus (OPN), and (f) superior colliculus (SC) in glycopyrrolate-treated mice at 6 weeks post-ONC. Scale bars: 50 µm. g The fluorescent intensity of CTB-positive axons in multiple visual targets of glycopyrrolate-treated mice was significantly higher than the vehicle-treated mice. Mean ± SEM (n = 3–4 per group). *P < 0.05, **P < 0.01; Student’s t test.
