Table 3 Factors influencing hepatic tissue maturation.
Factor | Effect on physiological maturation | Reference |
|---|---|---|
Environmental | ||
 3D culture | ↑ | |
 Endothelial co-culture | ↑ | |
Metabolic | ||
 Amino-acid enrichment | ↑ | |
 Bile acid supplementation | ↑ | |
 Microbially derived compound supplementation | ↑ | |
Signaling | ||
 Triiodothyronine | ↑ | |
 Oncostatin M and glucocorticoids | ↑ | |
Hepatocyte growth factor | Â | |
 Akt activation | ↑ | |
 AMPK activation | ↑ | |
 PKA activation | ↑ | |
