Table 6 Factors influencing intestinal maturation.
Factor | Effect on physiological maturation | Reference |
|---|---|---|
Environmental | ||
 3D culture | ↑ | |
 Hypoxia | ↑ | |
 (Flora) co-culture | ↑ | |
 Immune co-culture | ↑ | |
Metabolic | ||
 Short-chain fatty acid supplementation | ↑ | |
 Amino acid enrichment | ↑ | |
Signaling | ||
 mTOR activation | ↑ | |
 PPAR/TFAM activation | ↑ | |
 PGC1 activation | ↑ | |
