Fig. 3: Formation of endometrium-like tissues from hPSC-derived MDLCs in vivo. | npj Regenerative Medicine

Fig. 3: Formation of endometrium-like tissues from hPSC-derived MDLCs in vivo.

From: Bi-potential hPSC-derived Müllerian duct-like cells for full-thickness and functional endometrium regeneration

Fig. 3

a Schematic of hPSC-derived MDLCs transplanted beneath the renal capsule to form endometrium-like tissues. b Macroscopy of the white graft in transplanted site (arrowhead) of nude mice 8 weeks after xenotransplantation. c Histological staining of the mass and mouse kidney. Red scale bars, 200 μm. d Immunofluorescence for anti-human LAMIN (H-LAMIN) antigen in the mass, the H-LAMIN positive cells contain epithelial and stromal cells. Red scale bars, 200 μm; green scale bars, 40 μm. e Expression of PAX2 and KRT8 in the mass. Green scale bars, 40 μm. f Identification of specific endometrial makers ERα and PAEP in the mass. White scale bars, 10 μm.

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