Fig. 1: Tubular injury and PTCs rarefaction in I/R-induced AKI. | npj Regenerative Medicine

Fig. 1: Tubular injury and PTCs rarefaction in I/R-induced AKI.

From: Tubular epithelial cells-derived small extracellular vesicle-VEGF-A promotes peritubular capillary repair in ischemic kidney injury

Fig. 1

a Schematic diagram of the experimental design. Mice were subjected to a 28-min bilateral renal ischemia-reperfusion (I/R) injury and were euthanized at 1, 3, and 7 days after I/R. Schematic created with BioRender.com. b Changes in serum creatinine (sCr) following I/R injury (n = 6). c Representative images of PAS-stained kidneys. Scale bars, 100 μm. d Quantification of kidney injury based on PAS staining (n = 6). e RT-qPCR analysis of KIM-1 mRNA levels in kidneys (n = 6). f and g Representative confocal images of CD31-stained kidney sections. Scale bars, 50 μm. Quantification of PTC intensity based on six mice, with at least ten sections counted in each. Data are presented as means ± SD. **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. Sham group. One-way ANOVA.

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