Fig. 5: Anagen hair follicles change the transcriptional signature of mature scars.
From: Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue
a We used Transcriptomic Analysis Console to perform hierarchical clustering analysis on 719 genes that were differentially (|FC| > 1.5) and significantly (P < 0.01) regulated in the scar dermis before (0 mo) and after (2, 4, 6 mo) hair follicle transplantation. |FC| = absolute fold change (b) Venn diagram showing the transient transcriptomic changes to the scar dermis occurring post-transplant as compared to the baseline (0 mo). Asterix marks the core transcriptional signature which consists of 231 transcripts that were differentially regulated already at 2 months post-transplant and remained so throughout the follow-up period. c–e Ingenuity Pathway Analysis (IPA) analysis highlighting function terms in differentially regulated genes in the scar dermis after hair follicle transplantation. We selected functions terms that were relevant to the skin and had an |activation z-score| > 0.5. f–h Average signal of genes involved in functions terms relevant for the study, detected in the scar dermis before (0 mo) and after hair follicle transplantation (2, 4, 6 mo). i Downstream transcriptional network of secreted upstream regulators (P < 0.05) of the dataset of 231 core signature genes.
