Fig. 6: PTβR2I-releasing wound dressings prevented scar formation in diabetic wounds.

a α-SMA⁺ and CD31⁻ myofibroblast densities (n = 4) quantified from images in Fig. 4a and images stained on day 3. Myofibroblasts are identified as α-SMA⁺ cells that are not colocalized with CD31⁺ endothelial cells. α-SMA⁺ cells that are colocalized with CD31⁺ endothelial cells are vascular smooth muscle cells/pericytes. b PSR staining study of wound sections at 8- and 14-days post- treatment. Scale bar = 50 µm. c Relative total collagen contents in the wound area on days 8 and 14, based on acquired PSR images (n ≥ 5). d Ratios of collagen I to collagen III at two time points, from PSR images (n = 5). The ratio for healthy skin is 26.3, indicated with a dashed line. All data demonstrated as mean ± standard deviation. Data were analyzed by one-way ANOVA with Bonferroni post-test (*p < 0.05, **p < 0.01, ***p < 0.001).