Fig. 8: Mechanisms of accelerated diabetic wound healing achieved by using wound dressing containing PTβR2I and ROS-scavenging hydrogel. | npj Regenerative Medicine

Fig. 8: Mechanisms of accelerated diabetic wound healing achieved by using wound dressing containing PTβR2I and ROS-scavenging hydrogel.

From: Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing

Fig. 8

The PTβR2I gradually released from the wound dressing adaptively regulated TGFβ pathways by inhibiting p38 signaling while not interfering with Smad2/3 signaling. The hydrogel scavenged upregulated ROS in the wounds. As a result, the wound dressing promoted the survival and migration of skin cells, enhanced angiogenesis, and decreased tissue inflammation and oxidative stress.

Back to article page