Table 1 Studies on vitamin D and glucocorticoids show differing effects on cardiomyocyte proliferation and heart regeneration
From: Heart regeneration from the whole-organism perspective to single-cell resolution
| Â | Vitamin D | Glucocorticoids |
|---|---|---|
Mammals | Negative effect: Vitamin D treatment inhibited neonatal rodent cardiomyocyte proliferation in vitro50,51 No effect: Cardiac-specific vitamin D receptor knockout mice did not show any effect on cardiomyocyte proliferation at postnatal day 14 in vivo51 | Negative effect: Dexamethasone treatment inhibited neonatal rodent cardiomyocyte proliferation in vitro51. Glucocorticoid receptor ablation in mice after myocardial infarction led to cardiac muscle regeneration in vivo57 No effect: Cardiac-specific glucocorticoid receptor knockout mice did not alter cardiomyocyte proliferative activity at postnatal day 14 in vivo51 |
Zebrafish | Positive effect: Vitamin D analog enhanced zebrafish cardiomyocyte proliferation and heart regeneration while vitamin D receptor blockade inhibited regeneration52 | Negative effect: Dexamethasone /adrenaline55 and beclomethasone56 led to heart regeneration defects in zebrafish |
