Fig. 4: AAV9-cBIN1 improves LVEF with limited chamber dilation in minipigs with non-ischemic HFrEF. | npj Regenerative Medicine

Fig. 4: AAV9-cBIN1 improves LVEF with limited chamber dilation in minipigs with non-ischemic HFrEF.

From: Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs

Fig. 4

Echocardiography monitoring of LVEF (a) and LVEDV (b) in minipigs from baseline (RVP initiation timepoint) to terminal endpoint for each group (N = 3, 5, 4 from sham, control, and cBIN1 groups). Data are presented as mean ± standard error of the mean (SEM). Two-way ANOVA followed by Fisher’s LSD test for comparison among three groups was performed. *** indicates p < 0.001 for comparison vs. Sham. ### indicates p < 0.001 for comparison vs. Control.

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