Fig. 5: AAV9-cBIN1 rescues cardiac function in minipigs with non-ischemic HFrEF. | npj Regenerative Medicine

Fig. 5: AAV9-cBIN1 rescues cardiac function in minipigs with non-ischemic HFrEF.

From: Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs

Fig. 5

a Representative four-chamber view images of the minipig heart at end diastolic (top) and systolic (bottom) phases on termination day (left). Quantification of ejection fraction (EF) and stroke volume (SV) from each group (N = 3, 5, 4 from sham, control, and cBIN1 groups), (right). b Representative images of M-mode short axis view of the heart at termination (left). Quantification of left ventricular end-diastolic diameter (LVEDD) and relative wall thickness (RWT) (N = 3, 5, 4 from sham, control, and cBIN1 groups) (right). Data are presented as mean ± standard error of the mean (SEM). Ordinary one-way ANOVA followed by uncorrected Fisher’s LSD test is used for comparison among three groups. *, **, *** indicates p < 0.05, 0.01, 0.001 for comparison vs. Sham. #, ##, ### indicates p < 0.05, 0.01, 0.001 for comparison vs. Control.

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