Fig. 7: AAV9-cBIN1 ameliorates fluid retention in minipigs with non-ischemic HFrEF. | npj Regenerative Medicine

Fig. 7: AAV9-cBIN1 ameliorates fluid retention in minipigs with non-ischemic HFrEF.

From: Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs

Fig. 7

a Lung weight (LW) measured as the ratio of wet over dry lung weight of the minipigs at termination. b Thoracic cavity and abdominal fluid volume measured during termination procedure. c The mRNA level of Natriuretic Peptide B (NPPB) and Natriuretic Peptide A (NPPA) normalized to the housekeeping gene HPRT1 (quantified by ΔCt of NPPB/HPRT1 or NPPA/HPRT1) (LV samples/hearts: n/N = 15/3; 19/5, 20/4 from sham, control, and cBIN1 groups). Data are presented as mean ± standard error of the mean (SEM). Ordinary one-way ANOVA followed by uncorrected Fisher’s LSD test or non-parametric Kruskal-Wallis test followed by uncorrected Dunn’s test is used for comparison among three groups. *, *** indicates p < 0.05, 0.001 for comparison vs. Sham. #, ### indicates p < 0.05, 0.001 for comparison vs. Control.

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