Fig. 2: HA-Col click gels increased corneal re-epithelialization rate and decreased corneal opacity in rats. | npj Regenerative Medicine

Fig. 2: HA-Col click gels increased corneal re-epithelialization rate and decreased corneal opacity in rats.

From: Bio-orthogonal crosslinking and hyaluronan facilitate transparent healing after treatment of deep corneal injuries with in situ-forming hydrogels

Fig. 2

a Representative fluorescein staining photos of rat corneas from different treatment groups. b HA-Col click gel (HA-Col) treated corneas showed a higher probability of complete re-epithelialization over time compared to other groups although there were no significant differences among the treatments. n = 3 (PBS and HA-Col groups) or 4 (Col group). c Representative photos of rat corneas from different treatment groups at different time points. d Quantification of normalized central corneal opacity (gray value normalized to the peripheral cornea) showed the HA-Col treatment significantly decreased the corneal opacity compared to the Col click gel and PBS treatments on day 60. Data present means ± SEM. n = 8 (PBS group), 9 (HA-Col group), or 7 (Col group). The Heteroscedastic one-tail Student t-test was used to calculate the p values, *p < 0.05. HA is hyaluronic acid. Col is collagen. PBS is phosphate buffer solution. Graphs were created in GraphPad Prism 10.

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