Table 1 Characteristics of Donors in the Mayo Clinic Salivary Regenerative Biobanking
Characteristics | All Patients N = 208 (100%) | Male N = 113 (100%) | Female N = 95 (100%) |
|---|---|---|---|
Menopausal Status (Female only) | |||
Premenopausal | — | — | 5 (5.3%) |
Perimenopausal | — | — | 0 (0.0%) |
Postmenopausal | — | — | 57 (60.0%) |
Unknown | — | — | 33 (34.7%) |
Pregnancy | |||
Never | — | — | 14 (14.7%) |
1–2 | — | — | 19 (20.0%) |
> 2 | — | — | 21 (22.1%) |
Unknown | — | — | 41 (43.2%) |
BMI | |||
< 16 | 4 (1.9%) | 3 (2.6%) | 1 (1.1%) |
16–25 | 63 (30.3%) | 31 (27.4%) | 31 (33.7%) |
25–30 | 56 (26.9%) | 35 (31.0%) | 21 (22.1%) |
> 30 | 76 (36.5%) | 39 (34.5%) | 37 (38.9%) |
Unknown | 10 (4.8%) | 5 (4.4%) | 5 (5.3%) |
Race/Ethnicity | |||
White | 185 (88.9%) | 101 (89.4%) | 84 (88.4%) |
Hispanic/Latino | 4 (1.9%) | 2 (1.8%) | 2 (2.1%) |
Black/African American | 4 (1.9%) | 2 (1.8%) | 2 (2.1%) |
Native American/American Indian | 2 (1.0%) | 1 (0.9%) | 1 (1.05%) |
Asian/Pacific Islander | 3 (1.4%) | 2 (1.8%) | 1 (1.05%) |
Other | 1 (0.5%) | 0 (0.0%) | 1 (1.05%) |
Unknown | 9 (4.3%) | 5 (4.4%) | 4 (4.2%) |
Surgery (N = Total Alive) | 111 | 64 | 47 |
Unilateral partial parotidectomy | 70 (63.1%) | 39 (61.0%) | 31 (66.0%) |
Unilateral total parotidectomy | 30 (27.0%) | 18 (28.1%) | 12 (25.5%) |
Unilateral submandibulectomy | 8 (7.2%) | 5 (7.8%) | 3 (6.4%) |
Bilateral submandibulectomy | 3 (2.7%) | 2 (3.1%) | 1 (2.1%) |
Autopsy (N = Total Deceased) | 97 | 49 | 48 |
Bilateral submandibulectomy | 93 (95.9%) | 49 (100%) | 44 (91.7%) |
Unilateral submandibulectomy | 4 (4.1%) | 0 (0.0%) | 4 (8.3%) |
Cause of Death (N = Total Deceased) | 97 | 49 | 48 |
Cardiovascular | 31 (32.0%) | 16 (32.7%) | 15 (31.3%) |
Other organs* | 39 (40.2%) | 17 (34.7%) | 22 (45.8%) |
Cancer | 29 (29.9%) | 12 (24.5%) | 17 (35.4%) |
CNS | 24 (24.7%) | 16 (32.7%) | 8 (16.7%) |
Infections (excluding Covid) | 14 (14.4%) | 5 (10.2%) | 9 (18.8%) |
Diabetes | 16 (16.5%) | 9 (18.4%) | 7 (14.6%) |
Covid | 6 (6.2%) | 4 (8.2%) | 2 (4.2%) |
Unknown# | 4 (4.1%) | 2 (4.1%) | 2 (4.2%) |
Blunt force injuries | 5 (5.2%) | 3 (6.1%) | 2 (4.2%) |
Sialagogue Usage | |||
Pilocarpine | 1 (0.5%) | 1 (0.9%) | 0 (0.0%) |
Cevimeline | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
No | 202 (97.1%) | 109 (96.5%) | 93 (97.9%) |
Unknown | 5 (2.4%) | 3 (2.7%) | 2 (2.1%) |
Chronic Diseases | |||
Rheumatoid arthritis | 7 (3.4%) | 4 (3.5%) | 3 (3.1%) |
Sjögren’s syndrome | 1 (0.48%) | 0 (0.0%) | 1 (1.05%) |
Systemic lupus erythematosus | 1 (0.48%) | 0 (0.0%) | 1 (1.05%) |
Amyloidosis | 2 (1.0%) | 0 (0.0%) | 2 (2.1%) |
Primary biliary cirrhosis | 5 (2.4%) | 3 (2.6%) | 2 (2.1%) |
Diabetes mellitus | 44 (21.3%) | 24 (21.3%) | 20 (21.0%) |
Thyroiditis | 1 (0.5%) | 0 (0.0%) | 2 (2.0%) |
None | 146 (70.2%) | 81 (71.7%) | 65 (68.4%) |
Unknown | 5 (2.4%) | 3 (2.6%) | 2 (2.1%) |
History of Cancer | |||
Yes | 88 (42.3%) | 48 (42.5%) | 40 (42.1%) |
No | 115 (55.3%) | 62 (54.9%) | 53 (55.7%) |
Unknown | 5 (2.4%) | 3 (2.7%) | 2 (2.1%) |
History of Head & Neck Radiotherapy | |||
Yes | 20 (9.6%) | 13 (11.5%) | 7 (7.4%) |
No | 181 (87.0%) | 96 (85.0%) | 85 (89.5%) |
Unknown | 7 (3.4%) | 4 (3.5%) | 3 (3.2%) |
History of Chemotherapy | |||
Yes | 34 (16.3%) | 18 (15.9%) | 16 (16.8%) |
No | 168 (80.8%) | 92 (81.4%) | 76 (80.0%) |
Unknown | 6 (2.9%) | 3 (2.7%) | 3 (3.2%) |
Number of Medications | |||
None | 6 (2.9%) | 2 (1.8%) | 4 (4.2%) |
1-3 | 28 (13.5%) | 17 (15.0%) | 11 (11.6%) |
4-6 | 29 (13.9%) | 12 (10.6%) | 17 (17.9%) |
>6 | 139 (66.8%) | 79 (69.9%) | 60 (63.2%) |
Unknown | 6 (2.9%) | 3 (2.7%) | 3 (3.2%) |
Salivary Gland Neoplasm | |||
Warthin’s tumor | 3 (1.4%) | 3 (2.6%) | 0 (0.0%) |
Mucoepidermoid carcinoma | 1 (0.5%) | 0 (0.0%) | 1 (1.05%) |
None | 199 (95.7%) | 108 (95.6%) | 91 (95.8%) |
Unknown | 5 (2.4%) | 2 (1.8%) | 3 (3.2%) |
History of Covid-19 | |||
Yes | 41 (19.7%) | 18 (15.9%) | 23 (24.2%) |
No | 127 (56.9%) | 71 (62.9%) | 56 (59.0%) |
Unknown | 40 (19.2%) | 24 (21.2%) | 16 (16.8%) |
Neuropathy | |||
Parkinson | 4 (1.9%) | 4 (3.5%) | 0 (0.0%) |
Alzheimer | 6 (2.9%) | 4 (3.5%) | 2 (2.1%) |
Multiple sclerosis | 1 (0.5%) | 0 (0.0%) | 1 (1.05%) |
None | 193 (92.8%) | 103 (91.1%) | 90 (94.7%) |
Unknown | 5 (2.4%) | 2 (1.8%) | 3 (3.1%) |
Chronic Infections | |||
HCV | 2 (1.0%) | 1 (0.9%) | 1 (1.05%) |
HIV | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
EBV | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
CMV | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
None | 200 (96.1%) | 109 (96.5%) | 91 (95.8%) |
Unknown | 6 (2.9%) | 3 (2.6%) | 3 (3.2%) |
Smoking | |||
Current | 31 (14.9%) | 18 (15.9%) | 13 (13.7%) |
Former | 79 (38.0%) | 50 (44.2%) | 29 (30.5%) |
Never | 88 (42.3%) | 42 (37.2%) | 46 (48.4%) |
Unknown | 10 (4.8%) | 3 (2.6%) | 7 (7.4%) |
