Fig. 3: iMSCs improve the quality of wound healing.
From: Human iPSCs-derived mesenchymal stem cells promote skin regeneration and burn wound healing
A Macroscopic images of wounds on days 32 and 40 post-burn. On day 32, iMSCs-treated wounds exhibited complete wound closure, by day 32 while both control and acellular Integra groups still showed open wounds. By Day 40, all wounds showed complete closure. Black lines represent the initial dimensions of the excised wounds. B, C Statistical analysis of rate and the total amount of neo-epithelization, 10 K/cm2 iMSCS showed the highest levels compared to control groups. D simulated wound map displaying wound edge contraction. E Wound contracture rate analysis. iMSCs 5 and 10 K/cm2 show the lowest contraction. F Vancouver scar scale scoring, control wounds showed a slight, nonsignificant increase compared to the iMSCS-treated wound. Data is representative of three independent experiments (N = 3). Data presented as mean ± SEM, P * < 0.05, ** < 0.005, N = 3.
