Fig. 4: Col V is expressed in early infarcted myocardium. | npj Regenerative Medicine

Fig. 4: Col V is expressed in early infarcted myocardium.

From: Type V collagen from macrophages regulates initial collagen assembly and alignment in post-infarcted hearts

Fig. 4

Confocal imaging of an immunofluorescent-stained 4-chamber cross-section from a P1 heart at 1dpi showing injured area (green), endomucin (red) and Col V deposition (white; a–e). Immunofluorescent staining of Col I (f) and Col III (g) of serial sections in the same region as in (b). LV: left ventricle. RV: right ventricle. Scale bar: 100 μm. TEM showing cells with macrophages features in a P1 heart at 4dpi and proximal collagen fibrils (h, i). A magnified view of the inset box in (h) showing transverse section of collagen fibrils (j). TEM of a P7 heart at 4 dpi showing cells with macrophage features proximal to collagen fibrils (k, l). Magnified view from (k) showing close association of collagen fibrils and macrophages (m). Scale bar as indicated. M: macrophage. Cl: collagen. Ly: lysosome. Rb: rudiment body.

Back to article page