Fig. 2 | npj Schizophrenia

Fig. 2

From: Dopamine D2 receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances

Fig. 2

The circadian transcription/translation loop is comprised of rhythmically expressed “clock genes”. Circadian protein complexes containing BMAL1 drive expression of rhythmic genes including period (PER) and cryptochrome (CRY) through E-box DNA elements in promoters. PER/CRY negatively regulate their own expression. As PER/CRY degrade over several hours, BMAL1 activity increases and the cycle repeats. Time of onset (phase), duration (period), and strength (amplitude) of the cycle is regulated by multiple signaling pathway inputs. The figure was adapted from Landgraf et al. [Behavioral Neuroscience 128(3): 344–359, 2014] with permission from the American Psychological Association

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