Fig. 1

mRNA expression levels of inflammatory response genes and cytokines secreted after inducing a pro-inflammatory or anti-inflammatory phenotype in mo-MΦs of SCZ patients () and controls (). mRNA levels of inflammatory response genes after 6-h stimulation with LPS or R848 were not different between patients (n = 15) and controls (n = 15) a Five or one samples gave undetermined values for IL6 expression in the control and patient group, respectively. The basal cytokine levels (b) and fold change values after pro-inflammatory stimulation (c LPS and R848) of IL-6, TNFα and IL-10 in the medium were similar between SCZ patients and controls. The base level of IL-6 was undetermined for one patient sample. At base level and after LPS stimulation two and three undetermined values were present for TNFα secretion in controls and patients samples, respectively. After R848 stimulation four and three samples gave undetermined values for controls and patients, respectively. Both in the patient and the healthy control group, three samples gave undetermined values for IL-10 secretion. There was no difference measured between the patient (n = 14) and control group (n = 15) on mRNA levels of inflammatory response genes after 72-h anti-inflammatory stimulation with IL-4 or dexamethasone (d). After IL-4 stimulation three samples gave undetected values in CD200R1 expression in the control group and five in the patient group. CD200R1 mRNA values of four control and seven patient samples were undetermined after dexamethasone stimulation. One patient sample was undetected for CD163 expression after IL-4 stimulation. mRNA expression was analyzed with qPCR and cytokine secretion with ELISA. The mRNA values a, d were first normalized (2^Δct) with GAPDH as reference gene after which they were divided by the value of the sample without stimulation (dotted line) resulting in the fold change. The median is depicted with a black bar. Mann–Whitney U tests were used to compare the SCZ patients with the healthy controls. UND undetermined value