Fig. 5 | npj Schizophrenia

Fig. 5

From: Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone

Fig. 5

Summary of the main study hypothesis, experimental design and results. a Our major hypothesis. b Study design, research areas, experimental tests and outcomes of our study. Sdy polyI:C mice had more effects than the Sdy or PolyI:C alone groups. Note, the experimental design and timelines are colour-coded and coordinated with the experimental tests in (b) and overall hypothesis in (a). Also note Dtnbp1 is not expressed in Sdy samples. c Schematic diagram illustrating the main molecular and cellular results of the study. PolyI:C induced dysbindin-1 (Dtnbp1) expression, and Dtnbp1 enhanced Tlr3 expression in SVZ cells. Sandy SVZ cells that lack dysbindin-1 showed blocked Tlr3-RelA-Sp1 immune response to polyI:C. Microglial number was higher in postnatal Sandy SVZ than in WT controls. Leucocyte permeability was increased in postnatal SVZ of Sandy, but not WT mice given systemic polyI:C injections. Postnatal polyI:C injections reduced SVZ proliferation in postnatal Sandy mice, which continued to adulthood

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