Table 1 Fast differentiation of human-induced pluripotent stem cells (hiPSCs) or predifferentiated hiPSC neuronal stem cells (NSCs) to induced oligodendrocyte precursor cells (iOPCs) or induced oligodendrocytes (iOLs) by using selected expression of transcription factors

From: Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems

Cells used

Transcription factors

Generated cell stage

Days

References

hiPSCs

SOX10, OLIG2

iOPC (PDGFRα+/O4+)

14

Li et al.135

iOL (CNP+)

42

hiPSC NSCs

SOX10, OLIG2, NKX6.2a

iOPC (O4+)

28

Ehrlich et al.136

iOL (MBP+/CNP+)

35

hiPSCs

SOX10, OLIG2

iOPC (PDGFRα+/O4+)

10

Pawlowski et al.137

iOL (MBP+/PLP+/CNP+)

20

hiPSCs

NKX2.2

pre-iOPC (PDGFRα+)

30

Rodrigues et al.138

iOPC (O4+)

55

hiPSCs

SOX10a

iOL (O4+/MBP+/PLP+)

22

García-León et al.139

  1. aBest combination of transcription factors to reach (different) endpoint