Table 3 Effect of clinical subgroups on oligodendrocyted adjacent to microglia and myelin

From: Ultrastructural pathology of oligodendrocytes adjacent to microglia in prefrontal white matter in schizophrenia

 

Oligodendrocytes adjacent to microglia

  
 

Controls (n=20)

SPNS (n=9)

SPPS (n=12)

F(2,36)

p-value

Cohen’s d SPNS/Controls

Cohen’s d SPPS/Controls

Area of oligodendrocyte (μm2)

61.51±2.6

62.59±3.6

64.3±4.3

0.36

0.70

0.09

0.22

Area of nucleus (μm2)

18.16±1.0

17.54±1.4

19.11±1.3

0.57

0.57

0.14

0.21

Area of cytoplasm (μm2)

43.35±2.0

45.05±2.6

45.19±3.1

0.29

0.75

0.19

0.19

Nucleus.cytoplasm ratio

0.43±0.0

0.39±0.0

0.43±0

0.52

0.60

0.33

0.06

Area of mitochondria (μm2)

0.51±0.0

0.5±0.0

0.5±0.0

0.08

0.92

0.21

0.17

Vv of mitochondria (%)

4.53±0.5

3.03±1.0

2.49±0.3

3.91

0.03*

0.63

1.04

N of mitochondria

3.7±0.3

2.76±0.9

2.19±0.2

3.39

0.04*

0.52

1.10

Area of vacuoles (μm2)

1.38±0.3

0.97±0.1

1.77±0.5

0.66

0.52

0.33

0.27

Vv of vacuoles (%)

0.92±0.2

1.18±0.4

2.38±0.4

6.92

<0.01**

0.27

1.11

N of vacuoles

0.35±0.1

0.72±0.3

0.78±0.2

3.20

0.05

0.63

0.97

Area of lipofuscin granules (μm2)

1.62±0.3

1.67±0.3

1.61±0.3

0.01

0.99

0.05

0.01

Vv of lipofuscin granules (%)

0.64±0.2

2.04±0.6

1.81±0.3

8.41

<0.01**

1.08

1.08

N of lipofuscin granules

0.19±0.0

0.54±0.1

0.58±0.1

8.01

<0.01**

1.15

1.07

Cell density (N/mm2)

69.04±9.9

53.33±11.1

64.88±7.0

0.49

0.62

0.38

0.11

 

Oligodendrocytes adjacent to myelinated fibers

 

Controls (n=20)

SPNS (n=9)

SPPS (n=12)

F(2,36)

p-value

Cohen’s d SPNS/Controls

Cohen’s d SPPS/Controls

Area of oligodendrocyte (μm2)

63.43±2.4

64.48±3.0

65.48±3.2

0.11

0.89

0.10

0.19

Area of nucleus (μm2)

20.08±0.7

20.42±1.5

21.51±1.0

0.56

0.58

0.09

0.43

Area of cytoplasm (μm2)

43.34±1.9

44.06±2.2

43.97±2.3

0.02

0.98

0.09

0.07

Nucleus.cytoplasm ratio

0.47±0.0

0.47±0.0

0.49±0.0

0.35

0.71

0.01

0.36

Area of mitochondria (μm2)

0.53±0.0

0.5±0.0

0.59±0.1

0.57

0.57

0.36

0.27

Vv of mitochondria (%)

4.21±0.3

2.73±0.7

2.51±0.4

4.67

0.02*

0.83

1.02

N of mitochondria

3.42±0.3

2.29±0.5

2.23±0.4

3.26

0.05

0.81

0.84

Area of vacuoles (μm2)

1.67±0.3

1.55±0.3

1.11±0.2

0.83

0.44

0.12

0.55

Vv of vacuoles (%)

0.77±0.2

0.99±0.2

1.53±0.3

4.09

0.03*

0.32

0.78

N of vacuoles

0.22±0.0

0.29±0.1

0.69±0.1

11.53

<0.01***

0.35

1.14

Area of lipofuscin granules (μm2)

1.89±0.4

1.9±0.2

1.75±0.3

0.21

0.81

0.01

0.11

Vv of lipofuscin granules (%)

0.77±0.2

2.04±0.4

1.61±0.5

5.22

0.01*

1.16

0.69

N of lipofuscin granules

0.19±0.0

0.49±0.1

0.49±0.2

4.95

0.01*

1.14

0.76

Cell density (N/mm2)

144.2±22.0

122.5±18.5

84.45±18.5

1.76

0.19

0.25

0.65

  1. Estimates of the ultrastructural parameters and cell density (means ± S.E.M.) of oligodendrocytes adjacent to microglial cells and to myelinated fibers in the control group and in the SCZ subgroups with predominantly positive symptoms (SPPS) and with predominantly negative symptoms (SPNS) and between subgroups and control group differences (F and p-values, ANCOVA), Cohen’s d for SPNS/controls and for SPPS/controls
  2. *p < 0.05; **p < 0.01, ***p < 0.001
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