Fig. 3
From: Epigenetic clock analysis of blood samples from Japanese schizophrenia patients
Epigenetic age acceleration analysis of the GSE41169, GSE80417, and GSE84727 datasets. a, e, i Scatter-plots of DNA methylation age vs. chronological age. Spearman’s correlation analysis indicates a significant positive correlation between chronological age and DNA methylation age in both SCZ and control groups. b, c, d, f, g, h, j, k, l Box-plots of measures of epigenetic age acceleration represent as follows: centerline, median; box limits, upper and lower quartile; whiskers, 1.5 × interquartile range; points, outliers. Mann–Whitney U-test was performed for comparisons between SCZ and control groups. CTL, control; SCZ, schizophrenia; AgeAccel, universal epigenetic age acceleration; IEAA, intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration
